As of today, the need for practical skills and problem-solving capabilities remains largely unmet in many medical school curricula across Europe. Medical school education, in fact, remains largely anchored to a traditional paradigm of learning a discrete amount of information about pathophysiology principles and illnesses’ descriptions, without worrying about developing the skills necessary to work confidently “on the patient”. Digital tools based on macro-and microsimulation, thanks to their flexibility, effectiveness, accuracy and accessibility may give a fundamental contribution in solving this issue, and we want to apply their potential in undergraduate medical students’ education. The MEDSKILL school will allow students to: 1) get in touch with digital tools that facilitate the study of anatomy, physiology, pathophysiology and clinical reasoning; 2) confront virtual patients/mannequins, interpret their artificial symptoms/signs and make decisions, taking into account the appropriateness of the choice, as well as ethical correlates and sustainability; 3) mimic clinical situations to test patient communication skills, simulate the use of diagnostic equipment, team leaders and interventional therapies.